No, you do not need Salesforce to use Spiro.
You can use Spiro alone as your CRM that will let you manage your sales pipeline. Spiro can track account, contact and opportunity information which can be managed through our mobile apps and on the web.
With the Personal Edition of Spiro, you will be able to manage your own pipeline as well as export your forecast to excel.
With the Team Edition of Spiro, you can manage a team of people with roles and hierarchies. You will be also be able to view team analytics as well as create your own reports and dashboards for viewing.